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- Title
Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells.
- Authors
Eun Young Bae; Seung Woong Lee; Sin Seong; Wonjun Cho; Jong Seog Ahn; Hyun-Sug Cho
- Abstract
Endoplasmic reticulum (ER) stress is linked with development and maintenance of cancer, and serves as a therapeutic target for treatment of cancer. Verrucarin A, isolated from the broth of Fusarium sp. F060190, showed potential inhibitory activity on tunicamycin-induced ER stress in FaO rat liver cells. In addition, the compound decreased tunicamycin-induced GRP78 promoter activity in a dose dependent manner without inducing significant inhibition of luciferase activity and cell growth for 6 and 12 h. Moreover, the compound decreased the expression of GRP78, CHOP, XBP-1, and suppressed XBP-1, and reduced phosphorylation of IRE1α in FaO rat liver cells. This evidence suggests for the first time that verrucarin A inhibited tunicamycin-induced ER stress in FaO rat liver cells.
- Subjects
ENDOPLASMIC reticulum; CANCER treatment; FUSARIUM; TUNICAMYCIN; TRICHOTHECENES; LABORATORY rats
- Publication
Molecules, 2015, Vol 20, Issue 5, p8988
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules20058988