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- Title
A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031.
- Authors
Xiang-Zhong Huang; Yun Zhu; Xiao-Li Guan; Kai Tian; Jun-Ming Guo; Hong-Bin Wang; Guang-Miao Fu
- Abstract
Bioassay-guided fractionation of metabolites from the fungus Cephalosporium sp.AL031 isolated from Sinarundinaria nitida led to the discovery of a new isobenzofuranone derivative, 4,6-dihydroxy-5-methoxy-7-methylphthalide (1), together with three known compounds: 4,5,6-trihydroxy-7-methyl-1,3-dihydroisobenzofuran (2), 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (3) and 4,5,6-trihydroxy-7- methylphthalide (4). The structure of the new compound 1 was determined based on MS, 1D and 2D NMR spectral data. Compounds 1-4 showed potent antioxidant activity with EC50 values of 10, 7, 22 and 5 μM by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay.
- Subjects
ANTIOXIDANTS; METABOLITES; CEPHALOSPORIUM stripe; FURANONES; BIOLOGICAL assay
- Publication
Molecules, 2012, Vol 17, Issue 4, p4219
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules17044219