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- Title
Full genome sequence of Rocio virus reveal substantial variations from the prototype Rocio virus SPH 34675 sequence.
- Authors
Setoh, Yin Xiang; Amarilla, Alberto A.; Peng, Nias Y.; Slonchak, Andrii; Periasamy, Parthiban; Figueiredo, Luiz T. M.; Aquino, Victor H.; Khromykh, Alexander A.
- Abstract
Rocio virus (ROCV) is an arbovirus belonging to the genus Flavivirus, family Flaviviridae. We present an updated sequence of ROCV strain SPH 34675 (GenBank: AY632542.4), the only available full genome sequence prior to this study. Using next-generation sequencing of the entire genome, we reveal substantial sequence variation from the prototype sequence, with 30 nucleotide differences amounting to 14 amino acid changes, as well as significant changes to predicted 3'UTR RNA structures. Our results present an updated and corrected sequence of a potential emerging human-virulent flavivirus uniquely indigenous to Brazil (GenBank: MF461639).
- Subjects
BRAZIL; FLAVIVIRUSES; RNA sequencing; AMINO acid sequence; VIRAL variation
- Publication
Archives of Virology, 2018, Vol 163, Issue 1, p255
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-017-3561-4