We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association between Heroin Dependence and 5-HT<sub>2A</sub> Receptor Gene Polymorphisms.
- Authors
Sáiz, P. A.; García-Portilla, M. P.; Arango, C.; Morales, B.; Martínez-Barrondo, S.; Alvarez, C.; San Narciso, G.; Carreño, E.; Alvarez, V.; Coto, E.; Bobes, J.
- Abstract
Objective: To investigate the association between four polymorphisms of the 5-HT2A receptor and 5-HT transporter genes and heroin dependence. Methods: 113 heroin- dependent patients (DSM-IV criteria) and 420 unrelated healthy controls from Asturias (Northern Spain) were genotyped using standard methods. Results: There was an apparent difference in the distribution of genotypes for A-1438G polymorphisms (p = 0.024, not significant after Bonferroni correction). The 5-HT2A -1438A allele was significantly more common in patients than controls [0.55 and 0.45, respectively; corrected p = 0.042, OR = 1.51 (95% CI = 1.13–2.03)]. An interaction was observed between A-1438G of 5-HT2A and 5-HTT polymorphisms. The association between the -1438AA vs. AG/GG genotypes and heroin dependence was enhanced in the presence of 12-repeat 5-HTT VNTR and short 5-HTTLPR alleles [24.8% in heroin-dependent patients vs. 12.6% in controls; corrected p = 0.045, OR = 2.28 (95% CI = 1.36–3.82)]. Conclusions: Our findings support a contribution of the 5-HT2A gene to susceptibility to heroin dependence, as well as a possible synergistic effect of 5-HT2A and 5-HTT genes on susceptibility to heroin dependence. Copyright © 2008 S. Karger AG, Basel
- Subjects
ASTURIAS (Spain); SPAIN; GENETIC polymorphisms; HEROIN abuse; DRUG addiction; GENES
- Publication
European Addiction Research, 2008, Vol 14, Issue 1, p47
- ISSN
1022-6877
- Publication type
Article
- DOI
10.1159/000110410