We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Functional Phenotype of Alveolar Macrophages Features in Rats with Metabolic Syndrome.
- Authors
Voronkova, O. V.; Birulina, Yu. G.; Esimova, I. E.; Khasanova, R. R.; Ivanov, V. V.; Buyko, E. E.; Chernyshov, N. A.; Motlokhova, E. A.
- Abstract
Phenotypic characteristics of alveolar macrophages in the bronchoalveolar lavage fluid as well as their ability to acquire the M1 and M2 phenotypes during in vitro culturing with reprogramming factors were studied in rats with modeled diet-induced metabolic syndrome. A decrease in the number of alveolar macrophages with the M1 phenotype was found in animals with metabolic syndrome. The factors of metabolic syndrome do not affect phenotypic plasticity of cells in culture, but under the action of M2 reprogramming factors, the cells demonstrate a wide range of phenotypic plasticity by the CD80 and CD206 markers. The consistently high level of production of IL-6 and IL-10 by macrophages during culturing under different conditions indicates functional rigidity of the cells, which is probably a consequence of in vivo predetermined functional phenotype of these cells against the background of metabolic disorders.
- Publication
Bulletin of Experimental Biology & Medicine, 2023, Vol 175, Issue 5, p625
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-023-05914-y