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- Title
Search for osteoarthritis genetic markers in women with undifferentiated connective tissue dysplasia.
- Authors
Khusainova, R.; Tyurin, A.; Shapovalova, D.; Khusnutdinova, E.
- Abstract
We conducted an association study of ten polymorphisms in six candidate genes of OA ( rs1799750 (MMP1), rs35068180 (MMP3), rs2252070 (MMP13), rs63118460 and rs2276455 (COL2A1), rs143383 (GDF5), rs1544410, rs7975232, rs731236, and rs2228570 (VDR)) with the development of osteoarthritis (OA) in 333 women taking into account the localization of the pathological process, the age of disease manifestation, and ethnicity and investigated the presence of signs of undifferentiated connective tissue dysplasia (UCTD). On the basis of clinical and genetic data, we revealed statistically significant models to predict the development of osteoarthritis of various localizations (knee, hip, and generalized forms).
- Subjects
OSTEOARTHRITIS; DISEASES in women; DYSPLASIA; GENETICS
- Publication
Russian Journal of Genetics, 2017, Vol 53, Issue 7, p785
- ISSN
1022-7954
- Publication type
Article
- DOI
10.1134/S1022795417060072