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- Title
Synthesis of 4-ethyl-5-methyl-5,6-dihydrophenanthridine-8,9-diol as the key intermediate of potent agonists of the Wnt signalling pathway.
- Authors
Jing, Chen-xu; Cai, Jie-yun; Zhang, Yu; Chen, Duo-zhi; Hao, Xiao-jiang
- Abstract
The synthesis of 4-ethyl-5-methyl-5,6-dihydro-phenanthridine-8,9-diol as the key intermediate of a series of potent Wnt signalling pathway agonists is reported. This synthesis features a consecutive aryl-aryl and N-aryl coupling, leading to 4-ethyl-5-methyl-8,9-dimethoxyphenanthridin-6-(5H)-one, whose structure was determined by spectroscopic analysis and X-ray crystallography, in a one-pot sequence with the presence of palladium catalyst and TFP (tri(2-furyl)phosphine) as the ligand.
- Subjects
GLYCOL synthesis; PHENANTHRIDINE; CELLULAR signal transduction; PALLADIUM catalysts; CHEMICAL agonists; PHOSPHINE
- Publication
Journal of Chemical Research, 2015, Vol 39, Issue 4, p247
- ISSN
1747-5198
- Publication type
Article
- DOI
10.3184/174751915X14285852307852