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- Title
A Universal Method for Measuring Functional Activity of Complement in Humans, Laboratory, Domestic, and Agricultural Animals, Amphibians, and Birds.
- Authors
Kuleshina, O.; Kozlov, L.; Cheremnykh, E.
- Abstract
A new universal method for measuring activity of the serum complement system in humans, laboratory, domestic, agricultural animals, birds and amphibians is based on automated evaluation of the mortality of ciliate Tetrahymena pyriformis under the effect of the complement system. In contrast to the hemolytic method, measured activity of the complement shows no erroneously high results caused by reactive lysis in febrile patients. The method can be used for studies of the complement system in humans and animals without species-specifi c adaptation.
- Subjects
COMPLEMENT (Immunology); BLOOD proteins; HEMOLYSIS &; hemolysins; TETRAHYMENA pyriformis; CILIATA; PARASITIC protozoa
- Publication
Bulletin of Experimental Biology & Medicine, 2014, Vol 157, Issue 2, p285
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-014-2546-5