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- Title
Human genetics and disease: Mouse models of male infertility.
- Authors
Cooke, Howard J.; Saunders, Philippa T. K.
- Abstract
Spermatogenesis is a complex process that involves stem-cell renewal, genome reorganization and genome repackaging, and that culminates in the production of motile gametes. Problems at all stages of spermatogenesis contribute to human infertility, but few of them can be modelled in vitro or in cell culture. Targeted mutagenesis in the mouse provides a powerful method to analyse these steps and has provided new insights into the origins of male infertility.
- Subjects
SPERMATOGENESIS; MALE infertility; MUTAGENESIS
- Publication
Nature Reviews Genetics, 2002, Vol 3, Issue 10, p790
- ISSN
1471-0056
- Publication type
Article
- DOI
10.1038/nrg911