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- Title
Deep-inspiration breath-hold <sup>18</sup>F-FDG-PET/CT is useful for assessment of connective tissue disease associated interstitial pneumonia.
- Authors
Takeaki Uehara; Mitsuhiro Takeno; Maasa Hama; Ryusuke Yoshimi; Akiko Suda; Atsushi Ihata; Atsuhisa Ueda; Ukihide Tateishi; Yoshiaki Ishigatsubo
- Abstract
Objective: To examine clinical utility of 18F-flurodeoxyglucose (FDG)-positron emission tomography (PET)/CT for assessment of interstitial lung disease (ILD) in patients with connective tissue diseases (CTDs). Methods: A total of 69 18F-FDG PET/CT scans were conducted under deep inspiratory breath hold (DIBH) conditions in 45 CTD patients with ILD, including 16 dermatomyositis/polymyositis, nine systemic scleroderma and seven rheumatoid arthritis. Intensity and distribution of 18F-FDG signals in PET/CT were determined by standardized uptake value (SUVmax) and visual score in 18 regions, respectively. ILD was defined as active when immunosuppressive therapy was initiated or intensified. Results: Both SUVmax and visual score were higher in active phase (n=32) than inactive phase (n=37) (both p50.05), regardless of the underlying CTD and plain CT findings. The both parameters reduced after initiating or intensifying treatment in the follow-up study of 17 active patients except two died patients who showed increased visual score. Another two died patients showed high visual score (15 and 6/18, respectively). Changing ratio of visual score, but not SUVmax was correlated with KL-6 (r²=0.38, p50.05) and CRP (r²=0.52, p50.05). Conclusion: The DIBH 18F-FDG PET/CT procedure sensitively illustrates active ILD lesions in CTD and the extended signal distribution is associated with unfavorable clinical outcome.
- Subjects
PULMONARY fibrosis; CONNECTIVE tissue diseases; LUNG disease diagnosis; POSITRON emission tomography; IMMUNOSUPPRESSIVE agents
- Publication
Modern Rheumatology, 2016, Vol 26, Issue 1, p121
- ISSN
1439-7595
- Publication type
Article
- DOI
10.3109/14397595.2015.1054099