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- Title
Expression of CD44 in articular cartilage is associated with disease severity in knee osteoarthritis.
- Authors
Zhang, Fang-Jie; Luo, Wei; Gao, Shu-Guang; Su, Da-Zhi; Li, Yu-Sheng; Zeng, Chao; Lei, Guang-Hua
- Abstract
Objectives: To investigate CD44 levels in articular cartilage of knee osteoarthritis (OA) and the relationship between CD44 and severity of the disease. Methods: All 50 cartilage tissues included normal and OA cartilage, and were ascribed to the following four groups on the basis of modified Mankin score: normal, mild lesions, moderate lesions and severe lesions. CD44 levels in articular cartilage were assessed by immunohistochemical methods. Results: CD44 levels were detected in all four groups. The difference in average gray value of CD44 expression showed statistical significance when compared between each group ( P < 0.05). In addition, CD44 expression in each group correlated with disease severity, according to the modified Mankin score ( ρ = −0.848, P < 0.01). Conclusions: CD44 in articular cartilage is associated with progressive knee OA joint damage.
- Subjects
CD44 antigen; ARTICULAR cartilage; SEVERITY of illness index; OSTEOARTHRITIS; KNEE diseases; IMMUNOHISTOCHEMISTRY
- Publication
Modern Rheumatology, 2013, Vol 23, Issue 6, p1186
- ISSN
1439-7595
- Publication type
Article
- DOI
10.3109/s10165-012-0818-3