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- Title
STATUS OF ZINC AND SELENIUM IN IRAQI WOMEN WITH RHEUMATOID ARTHRITIS AND SECONDARY OSTEOPOROSIS.
- Authors
Shareef, Baraa Hussain; Hasan, Bushra F.
- Abstract
Rheumatoid arthritis (RA) is an inflammatory joint disease with a prevalence of about 5 per 1000 adults around the world. The disease affects women two to three times more than men. OSP is a significant RA complication and it’s considered one of the widely known complication of RA, with 15%-20% of RA patients suffering from hip and spine affliction. The Aim of this study was to measure mineral levels (Zn) and (Se) in patients with RA and secondary OSP and compare them to RA patients and controls and to study the association of these minerals to some parameters in each patient group. The study included 90 Iraqi women, (30) with RA, (30) with RA and secondary OSP and (30) healthy control subjects. The age range for the samples is (20-70) years. Zinc (Zn), selenium (Se) and C - reactive protein (CRP) also erythrocyte sedimentation rate (ESR), bone mineral density (BMD) were measured. Patients simplified disease activity score (SDAI) and disease duration were also measured. The findings of the study showed a highly significant decrease in Zn, Se and inflammatory markers C-RP and ESR levels in patient groups compared to control LSD values(0.106, 0.0138, 1.0626, 9.7047), respectively. BMD measurements demonstrated a highly significant decrease in patient groups compared to control with (0.263) LSD value in which it was lower in RA patients with OSP. SDAI showed a non-significant yet a slight increase in RA and secondary OSP group compared to RA group with (0.65) P-value, while disease duration estimation between the two groups showed a highly significant difference with (0.0001) P-value. Conclusion: Rheumatoid arthritis patients with and without secondary osteoporosis have lower Zn, Se, CRP, ESR, BMD when compared to healthy control subjects. BMD was lower in RA and Secondary osteoporosis patients while Zn level was higher. SDAI showed no significant difference between patient groups, while disease duration was significantly higher in RA patients with secondary osteoporosis. According to our study result mineral estimation can be considered as a non-invasive indicator for RA and mineral supplementation may play a major protective role against osteoporosis.
- Subjects
RHEUMATOID arthritis; DISEASE prevalence; OSTEOPOROSIS; SELENIUM; ZINC
- Publication
Biochemical & Cellular Archives, 2021, Vol 21, Issue 1, p1185
- ISSN
0972-5075
- Publication type
Article