We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
ASSOCIATION OF LOW DENSITY LIPOPROTEIN RECEPTOR GENE POLYMORPHISM (rs6511720 AND rs11669576) WITH CORONARY ARTERY DISEASE IN IRAQI POPULATION.
- Authors
Hussain, Majid Kadhum; Algenabia, Abdul Hussein A.; Alkhateeb, Zainb M. J.; Rgeeb, Ahmed
- Abstract
Coronary artery disease is a serious health problem in the world as well as in Iraq. The genetic background of the disease is still unclear in particular, the involvement of low density lipoprotein receptor gene polymorphisms. Aim: To assess the influence of 2 SNPs (rs6511720 and rs11669576) of low density lipoprotein receptor gene on the development of coronary artery disease and serum lipid concentrations in Iraqi population. Five hundreds individuals were recruited in a case control study, 250 patients with coronary artery disease and 250 healthy persons. Serum lipid concentrations were determined by standards methods. Genotyping of low density lipoprotein receptor gene polymorphisms (rs6511720 and rs11669576) was achieved by restriction fragment length polymorphism-polymerase chain reaction. Patients carried the genotype TT+GT of the rs6511720G>T SNP were found to be significantly (P: 0.025) increased in comparison to those in the healthy group when the analysis was achieved under the additive model. The minor allele frequency was evident to be significantly (OR: 1.39; 95%CI: 1.00-1.93; P: 0.046) elevated in the patients relative to the control individuals. Data of the rs11669576G>A SNP explored a significant elevation of patients carried the genotypes GA+AA relative to the control persons under the dominant model (P: 0.039) and the additive model (P: 0.0001). The minor allele frequency showed a significant (OR: 1.31; %95CI: 1.01- 1.69; P: 0.034) increment in the group of patients when compared with the control group. HDL-c concentration was found to be significantly (P: 0.022 for the T allele of rs6511720G>T SNP and P: 0.011 for the A allele of rs11669576G>A) elevated in the patients group relative to the control group when the assessment was achieved under the codominant model. The 2 investigated SNPs were associated with CAD in Iraqi population, but not with LDL-c concentration. However, such association was evident with HDL-c concentration
- Subjects
CORONARY artery abnormalities; LOW density lipoproteins; BLOOD lipoprotein metabolism; GENETIC polymorphisms; PUBLIC health
- Publication
Biochemical & Cellular Archives, 2021, Vol 21, Issue 1, p203
- ISSN
0972-5075
- Publication type
Article