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- Title
Ototoxicity of oral neomycin and vancomycin.
- Authors
Kavanagh, Kevin T.; McCabe, Brian F.; Kavanagh, K T; McCabe, B F
- Abstract
In contrast to parenteral neomycin, which may result in severe and progressive ototoxicity, oral neomycin has been widely used for 25 years, and its index of safety has been regarded as high. Ototoxicity is viewed as an uncommon complication of oral neomycin most likely to occur in patients with renal failure or gastrointestinal inflammation. Two cases of ototoxicity resulting from oral neomycin are presented. Serial audiometric and neomycin blood level testing are suggested as a means of auditory monitoring in patients receiving the drug. A review of experience with oral vancomycin indicates that this drug has not been shown to cause ototoxicity.
- Publication
Laryngoscope, 1983, Vol 93, Issue 5, p649
- ISSN
0023-852X
- Publication type
journal article
- DOI
10.1002/lary.1983.93.5.649