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- Title
Material selection as a control strategy to limit hydrogen peroxide residuals in drug products.
- Authors
Widmann, Claudia; Ravasio, Davide; Ladwig, Theresa
- Abstract
Aseptically processed pharmaceutical products and packages may be exposed to hydrogen peroxide (H2O2) throughout the filling and packaging process. While the advantage of the decontamination with H2O2 lies in its harmless end-products water and oxygen, residual hydrogen peroxide may show detrimental effects on sensitive pharmaceutical products, even at trace concentrations. Therefore, the transmission rate of H2O2 through the packaging material (e.g. polymer packaging foils) during a decontamination process needs to be determined to prevent H2O2 ingress into the product. Thus, in this study, a methodology capable of generating H2O2 interaction data is proposed, which may be used for packaging material selection.
- Subjects
PACKAGING materials; OXYGEN in water; ASEPTIC packaging
- Publication
TechnoPharm, 2021, Vol 11, Issue 2, p100
- ISSN
2191-8341
- Publication type
Article