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- Title
Efficacy of topical gabapentin in women with primary macular amyloidosis: A side‐by‐side triple‐blinded randomized clinical trial.
- Authors
Abtahi‐Naeini, Bahareh; Hemati, Elahe; Faghihi, Gita; Shahmoradi, Zabihollah; Paknazar, Fatemeh; Rastegarnasab, Fereshte; Varshosaz, Jaleh; Hadian, Mahdi; Akbari, Mojtaba; Sabzghabaee, Ali Mohammad
- Abstract
Background: Primary cutaneous macular amyloidosis (PCMA) is a chronic pruritic cutaneous disease characterized by heterogeneous extracellular deposition of amyloid protein in the skin. Aims: This study aimed to evaluate the efficacy of topical 6% gabapentin cream for the treatment of patients with PCMA. Materials and Methods: In this triple‐blind clinical trial, a total of 34 patients, who were diagnosed with PCMA, treated using two different strategies of topical gabapentin as the active group and vehicle cream as the control group. Results: Pruritus score reduction in both groups was statistically significant compared with the baseline value (p < 0.001). There was a significant pigmentation score reduction in intervention group compared with control group after 1 month of the study (p < 0.001). The differences of pigmentation score changes between the groups were not significant at month 2 (p = 0.52) and month 3 (p = 0.22). Conclusions: The results of this study suggest that topical gabapentin cream may be effective as a topical agent in the treatment of pruritus associated with PCMA without any significant adverse effects. It is recommended to perform similar studies with a larger sample size and longer duration in both sexes.
- Subjects
CLINICAL trials; AMYLOIDOSIS; GABAPENTIN; SKIN proteins; SKIN diseases
- Publication
Journal of Cosmetic Dermatology, 2024, Vol 23, Issue 5, p1677
- ISSN
1473-2130
- Publication type
Article
- DOI
10.1111/jocd.16180