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- Title
Genomic Analysis of a Hybrid Enteroaggregative Hemorrhagic Escherichia coli O181:H4 Strain Causing Colitis with Hemolytic-Uremic Syndrome.
- Authors
Kislichkina, Angelina A.; Kartsev, Nikolay N.; Skryabin, Yury P.; Sizova, Angelika A.; Kanashenko, Maria E.; Teymurazov, Marat G.; Kuzina, Ekaterina S.; Bogun, Alexander G.; Fursova, Nadezhda K.; Svetoch, Edward A.; Dyatlov, Ivan A.
- Abstract
Hybrid diarrheagenic E. coli strains combining genetic markers belonging to different pathotypes have emerged worldwide and have been reported as a public health concern. The most well-known hybrid strain of enteroaggregative hemorrhagic E. coli is E. coli O104:H4 strain, which was an agent of a serious outbreak of acute gastroenteritis and hemolytic uremic syndrome (HUS) in Germany in 2011. A case of intestinal infection with HUS in St. Petersburg (Russian Federation) occurred in July 2018. E. coli strain SCPM-O-B-9427 was obtained from the rectal swab of the patient with HUS. It was determined as O181:H4-, stx2-, and aggR-positive and belonged to the phylogenetic group B2. The complete genome assembly of the strain SCPM-O-B-9427 contained one chromosome and five plasmids, including the plasmid coding an aggregative adherence fimbriae I. MLST analysis showed that the strain SCPM-O-B-9427 belonged to ST678, and like E. coli O104:H4 strains, 2011C-3493 caused the German outbreak in 2011, and 2009EL-2050 was isolated in the Republic of Georgia in 2009. Comparison of three strains showed almost the same structure of their chromosomes: the plasmids pAA and the stx2a phages are very similar, but they have distinct sets of the plasmids and some unique regions in the chromosomes.
- Subjects
SAINT Petersburg (Russia); GEORGIA (Republic); HEMOLYTIC-uremic syndrome; GENOMICS; ESCHERICHIA coli; CHROMOSOME structure; COLITIS; SCHMALLENBERG virus; CAMPYLOBACTER jejuni
- Publication
Antibiotics (2079-6382), 2022, Vol 11, Issue 10, pN.PAG
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics11101416