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- Title
Evaluation of Pneumococcal Surface Protein A as a Vaccine Antigen against Secondary Streptococcus pneumoniae Challenge during Influenza A Infection.
- Authors
Roberts, Sean; Williams, Clare M.; Salmon, Sharon L.; Bonin, Jesse L.; Metzger, Dennis W.; Furuya, Yoichi
- Abstract
Secondary bacterial pneumonia is responsible for significant morbidity and mortality during seasonal and pandemic influenza. Due to the unpredictability of influenza A virus evolution and the time-consuming process of manufacturing strain-specific influenza vaccines, recent efforts have been focused on developing anti-Streptococcus pneumoniae immunity to prevent influenza-related illness and death. Bacterial vaccination to prevent viral-bacterial synergistic interaction during co-infection is a promising concept that needs further investigation. Here, we show that immunization with pneumococcal surface protein A (PspA) fully protects mice against low-dose, but not high-dose, secondary bacterial challenge using a murine model of influenza A virus-S. pneumoniae co-infection. We further show that immunization with PspA is more broadly protective than the pneumococcal conjugate vaccine (Prevnar). These results demonstrate that PspA is a promising vaccine target that can provide protection against a physiologically relevant dose of S. pneumoniae following influenza infection.
- Subjects
STREPTOCOCCUS pneumoniae; INFLUENZA; SEASONAL influenza; PNEUMOCOCCAL vaccines; VACCINES
- Publication
Vaccines, 2019, Vol 7, Issue 4, p146
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines7040146