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- Title
Comparative Assessment of the Toxicity of Brominated and Halogen-Free Flame Retardants to Zebrafish in Terms of Tail Coiling Activity, Biomarkers, and Locomotor Activity.
- Authors
Rialto, Taisa Carla Rizzi; Marino, Renan Vieira; Abe, Flavia Renata; Dorta, Daniel Junqueira; Oliveira, Danielle Palma
- Abstract
BDE-47, a flame retardant that is frequently detected in environmental compartments and human tissues, has been associated with various toxic effects. In turn, information about the effects of aluminum diethyl-phosphinate (ALPI), a halogen-free flame retardant from a newer generation, is limited. This study aims to assess and compare the toxicity of BDE-47 and ALPI to zebrafish by analyzing the tail coiling, locomotor, acetylcholinesterase activities, and oxidative stress biomarkers. At 3000 µg/L BDE-47, the coiling frequency increased at 26–27 h post-fertilization (hpf), but the burst activity (%) and mean burst duration (s) did not change significantly. Here, we considered that the increased coiling frequency is a slight neurotoxic effect because locomotor activity was impaired at 144 hpf and 300 µg/L BDE-47. Moreover, we hypothesized that oxidative stress could be involved in the BDE-47 toxicity mechanisms. In contrast, only at 30,000 µg/L did ALPI increase the catalase activity, while the motor behavior during different developmental stages remained unaffected. On the basis of these findings, BDE-47 is more toxic than ALPI.
- Subjects
FIREPROOFING agents; POISONS; ZEBRA danio embryos; BRACHYDANIO; OXIDATIVE stress; BIOMARKERS
- Publication
Toxics, 2023, Vol 11, Issue 9, p732
- ISSN
2305-6304
- Publication type
Article
- DOI
10.3390/toxics11090732