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- Title
Effects of a Low-Fat Diet on Levels of Oxidative Damage to DNA in Human Peripheral Nucleated Blood Cells.
- Authors
Djuric, Zora; Heilbrun, Lance K.; Reading, Bruce A.; Boomer, Allison; Valeriote, Frederick A.; Martino, Silvana
- Abstract
Fat in the diet has been associated with increased breast cancer risk. In this study, blood samples were obtained from 21 women at high risk for breast cancer who had been randomly assigned to either a nonintervention diet or a low-fat diet. Oxidative damage was examined in the DNA from nucleated peripheral blood cells. The levels of oxidized thymine, specifically 5-hydroxymethyluracil, were threefold higher in the nonintervention diet group than in the low-fat diet group. Without regard to diet arm, there also was a significant linear relationship between daily total fat intake and 5-hydroxymethyluracil level. These results suggest that oxidative damage to DNA may be a marker of dietary fat intake. In addition, oxidative DNA damage may be a mechanistic link between fat in the diet and cancer risk, since such damage is associated with the process of tumor promotion.
- Publication
JNCI: Journal of the National Cancer Institute, 1991, Vol 83, Issue 11, p766
- ISSN
0027-8874
- Publication type
Article