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- Title
Intravitreal bevacizumab for choroidal neovascularization secondary to Vogt-Koyanagi-Harada syndrome.
- Authors
Teodoro Evans; Mario Saravia; Ariel Schlaen; Cristobal Couto
- Abstract
Abstract Background Vogt-Koyanagi-Harada (VKH) syndrome is characterized by bilateral diffuse uveitis associated with auditory, neurological, and cutaneous signs and symptoms. VKH syndrome is a cell-mediated autoimmune disease against melanocytes. Choroidal neovascularization (CNV) occurs in 15% of VKH patients and is associated with poor visual prognosis. Cases We report on two patients with VKH syndrome and CNV that were treated with intravitreal bevacizumab. Observations One of the VKH patients also had an extrafoveal CNV membrane and underwent multiple intravitreal injections of bevacizumab in combination with laser photocoagulation, with subsequent improvement in visual acuity. The second had a subfoveal CNV that responded to a single intravitreal injection of bevacizumab. Conclusion Intravitreal bevacizumab may be a useful drug to treat CNV in eyes with VKH syndrome.
- Subjects
BEVACIZUMAB; DRUG efficacy; UVEITIS; CHOROID diseases; MELANOCYTES; AUTOIMMUNE diseases; CELLULAR immunity; LASER coagulation
- Publication
Japanese Journal of Ophthalmology, 2009, Vol 53, Issue 1, p57
- ISSN
0021-5155
- Publication type
Article