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- Title
Evaluation of Total and Allergen-Specific Secretory IgA in Tears of Allergic Conjunctival Disease Patients.
- Authors
Noriko Inada; Jun Shoji; Mai Hoshino; Mitsuru Sawa
- Abstract
Abstract Purpose To investigate the variations in total secretory IgA (sIgA) and house dust mite (HDM)-specific sIgA antibodies in tears of patients with allergic conjunctival disease (ACD). Methods The subjects comprised 40 patients (40 eyes) with ACD and 21 healthy individuals as a control. Patients with ACD comprised three groups: 16 patients (16 eyes) with perennial allergic conjunctivitis (PAC group), 11 patients (11 eyes) with atopic keratoconjunctivitis (AKC group), and 13 patients (13 eyes) with vernal keratoconjunctivitis (VKC group). Tear samples were taken by the Schirmer I method using filter paper. Tear samples were eluted and analyzed for total sIgA and HDM-specific sIgA antibodies in tears by enzyme-linked immunosorbent assay. Results The mean (�SD) value of total sIgA in tears in the control, PAC, AKC, and VKC groups was 1446.7 � 1220.1, 706.8 � 567.2, 440.4 � 151.8, and 460.8 � 340.6 �g/ml, respectively. Total sIgA values were significantly lower in the VKC group than in the control group. We defined the HDM index as the ratio of HDM-specific sIgA to total sIgA. The HDM index in the VKC (P P P Conclusions Low levels of total sIgA and high levels of HDM-specific sIgA indicate a local pathogenic factor in ACD. Jpn J Ophthalmol 2007;51:338–342 � Japanese Ophthalmological Society 2007
- Subjects
CONJUNCTIVITIS; TEARS (Body fluid); IMMUNOGLOBULINS; EYE diseases; OPHTHALMOLOGY
- Publication
Japanese Journal of Ophthalmology, 2007, Vol 51, Issue 5, p338
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-007-0462-1