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- Title
Software package for integrated data processing for internal dose assessment in nuclear medicine (SPRIND).
- Authors
Visser, Eric; Postema, Ernst; Boerman, Otto; Visschers, Jeroen; Oyen, Wim; Corstens, Frans
- Abstract
Internal radiation dose calculations are normally carried out using the Medical Internal Radiation Dose (MIRD) schema. This requires residence times of radiopharmaceutical activity and S-values for all organs of interest. Residence times can be obtained by quantitative nuclear imaging modalities. For dealing with S-values, the freeware packages MIRDOSE and, more recently, OLINDA/EXM are available. However, these software packages do not calculate residence times from image data. For this purpose, we developed an IDL-based software package for integrated data processing for internal dose assessment in nuclear medicine (SPRIND). SPRIND allows reading and viewing of planar whole-body scintigrams. Organ and background regions of interest (ROIs) can be drawn and are automatically mirrored from the anterior to the posterior view. ROI statistics are used to obtain anterior-posterior averaged counts for each organ, corrected for background activity and attenuation. Residence times for each organ are calculated based on effective decay. The total body biological half-time is calculated for use in the voiding bladder model. Red bone marrow absorbed dose can be calculated using bone regions in the scintigrams or by a blood-derived method. Finally, the results are written to a file in MIRDOSE-OLINDA/EXM format. Using scintigrams in DICOM, the complete analysis is gamma camera vendor independent, and can be performed on any computer using an IDL virtual machine. SPRIND is an easy-to-use software package for radiation dose assessment studies. It has made these studies less time consuming and less error prone.
- Subjects
COMPUTERS in medicine; NUCLEAR medicine; COMPUTER software; MEDICAL radiology; IDL (Computer program language); GAMMA (Electronic computer system)
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2007, Vol 34, Issue 3, p413
- ISSN
1619-7070
- Publication type
Article
- DOI
10.1007/s00259-006-0226-z