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- Title
Effect of simvastatin on bone mineral density of the calcaneus in postmenopausal women with hyperlipoidemia.
- Authors
LIU Xiaoning; PENG Fengqin; KONG Dcngming; ZHANG Xinmei; JU Yang
- Abstract
Objective To evaluated the effect of simvastatin on bone mineral density (BMD) of the calcaneus in postmenopausal women with hypcrlipidemia. Methods BMD of the calcaneus of 885 postmenopausal women with hyperlipidemia (TC > 5.18 mmol/L or LDL-C > 3.37 mmol/L) were studied. Simvastatin was used in these women. According to the T-score, normal bone mass, osteopenia, and osteoporosis were diagnosed. Results BMD of the calcaneus was 305.3 ± 59.2 mg/cm2 before the treatment. The number of people with normal bone mass, osteopenia, and osteoporosis were 115, 446, and 324, respectively. After simvastatin administration (20 mg/d) for 3 months, the BMD was 309.7 ± 56.3 mg/cm2. The number of people with normal bone mass, osteopenia, and osteoporosis were 117, 459, and 319, respectively. After a 12-month treatment, BMD of the calcaneus was 312.5 ± 60.9 mg/cm2. The number of people with normal bone mass, osteopenia, and osteoporosis were 122, 460, and 303, respectively. Conclusion After a 12-month simvastatin (20 mg/kg · d) administration, BMD of the calcaneus postmenopausal women with hyperlipidcmia. It can not affect the risk of osteoporosis for these women.
- Publication
Chinese Journal of Osteoporosis, 2014, Vol 20, Issue 10, p1236
- ISSN
1006-7108
- Publication type
Article