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- Title
Effect of short-term hypothyroidism after the surgery for thyroid carcinoma on bone mineral density and fat distribution.
- Authors
ZHANG Jinhe; YIN Jilin; DENG Weimin; WANG Cheng; YU Hui; ZHANG Ming; LIANG Ying; AN Wenfeng; JIANG Lisha
- Abstract
Objective To observe the effect of short-term hypothyroidism after the surgery for hyroid carcinoma on bone mineral density BMD) and fat distribution, and to investigate the correlation between them. Methods Twenty-two patients with thyroid cancer were selected. All these patients underwent total thyroidectomy or subtotal resection. The 1311 removal treatment began at the 4th to the 8th week after the operation or at the 3rd to the 6th week after the discontinuation of levothyroxine. The application of levothyroxine started at the 4Sth hour after the 1311 removal treatment. BMD and fat distribution of all the patients were detected before the operation, before the 1311 treatment, and 3-6 months after the treatment of 1311, respectively. Results Among all these 22 patients with thyroid cancer, the average levels of free triiodothyronine (FT3 I before the operation, 4-6 weeks after operation. and 3-6 months after treatment of 1311 were 4. 55 ± 0. 91 pmol/L. 1.21 ± 0.41 pmol/L, and 5. 70 ± 1. 17 pmol/L, respectively. BMD determination showed no significant changes. The body fat contents were 21.75 ±8.01 kg. 23.05 ±7.% kg. 21. 53 ±7. 73 kg. respectively. Body fat content increased significantly during hypothyroidism l. the second level minus the first one. (P <0. 01). After recovering from hypothyroidism, body fat content also recovered < the third level minus the first one, P = 0. 36). Conclusion The short-term hypothyroidism has no effect on BMD of the patients, but can make the body fat content increase significantly. And the changes gradually recover after the correction of hypothyroidism.
- Publication
Chinese Journal of Osteoporosis, 2014, Vol 20, Issue 7, p747
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969.j.issn.1006-7108.2014.007.006