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- Title
Involvement ofHydra achaete-scutegeneCnASHin the differentiation pathway of sensory neurons in the tentacles.
- Authors
Hayakawa, Eisuke; Fujisawa, Chiemi; Fujisawa, Toshitaka
- Abstract
The proneural genes ofachaete-scute(ac-sc) family that encodes the bHLH class transcription factors play a variety of roles in neurogenesis. InHydra, theac-schomologueCnASHis involved in nematocyte differentiation. In the present study, we found that sensory neurons in the tentacles expressedCnASH, in addition to differentiating nematocytes in the body column ofHydra. Neuron precursors that migrated to the tentacle base did not expressCnASH, and it took 1 day for them to becomeCnASH-expressing neurons. Thus, theCnASH-positive cells at the tentacle base appeared to be sensory cells at early stages of differentiation. Furthermore, theCnASH-positive neurons distributed from the base to the tip of tentacles suggest that the gene is also involved in maintenance of the differentiated state. In addition, we found that the sensory neurons in the tentacles consist of at least two subpopulations. The comparison of theCnASHexpression with Nv1 expression in sensory cells that is detected by monoclonal antibody Nv1 showed that at least Nv1-positive/CnASH-positive and Nv1-negative/CnASH-positive sensory neurons existed in the tentacles.
- Subjects
SENSORY neurons; TRANSCRIPTION factors; NEURONS; MONOCLONAL antibodies; GENES; DEVELOPMENTAL neurobiology
- Publication
Development Genes & Evolution, 2004, Vol 214, Issue 10, p486
- ISSN
0949-944X
- Publication type
Article
- DOI
10.1007/s00427-004-0430-4