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- Title
Nanocargo-Delivery Platform for Targeted Drug Delivery in Biomedical Applications: Magnetic Gd<sub>2</sub>O<sub>3</sub> Nanoparticles in Porous SiO<sub>2</sub>.
- Authors
ŽID, L.; ZELEŇÁK, V.; BERKUTOVA, A.; SZŨCSOVÁ, J.; ZELEŇÁKOVÁ, A.
- Abstract
We investigated nanocargo-delivery magnetic platform composed of spherical Gd2O3 particles, loaded together with cytostatic drug 5-fluorouracil (5-FU) in periodic mesoporous silica matrix. The system under study combined the advantages of high surface area and pore volume of mesoporous silica cargo with the advantages of magnetic separability and targeted drug delivery, provided by magnetic Gd2O3 nanoparticles. The sample was characterized by HRTEM (High-Resolution Transmission ElectronMicroscopy), PXRD (powder X-ray diffraction), elemental analysis, and magnetic measurements by MPMS apparatus. A conventional paramagnetic response was observed in the whole 5-330 K range with high magnetization about 90 emu/g at 50 000 Oe. Effective magnetic moment per formula unit 7.88 μB obtained at room temperature is close to theoretical value 7.94 μB. The released amount of 5-FU represented more than 90% of the loaded one.
- Subjects
TARGETED drug delivery; MAGNETICS; MESOPOROUS silica; MAGNETIC measurements; ANTINEOPLASTIC agents; MAGNETIC nanoparticles; X-ray powder diffraction
- Publication
Acta Physica Polonica: A, 2020, Vol 137, Issue 5, p773
- ISSN
0587-4246
- Publication type
Article
- DOI
10.12693/APhysPolA.137.773