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- Title
Cardioprotective Effects of Ethanolic Extract of Cedrus deodara Roxb against Isoproterenol Induced Myocardial Infarction in Rats.
- Authors
Chellammal, Hanish Singh Jayasingh; D., Praveen Kumar; Kshirsagar, Rahul P.; Hasan, Mizaton Hazizul; Diwan, Prakash V.
- Abstract
Myocardial infarction (MI) is an ischaemic heart disease. Herbal drugs were some treatment options, and the current study explored the cardioprotective effects of Cedrus deodara ethanolic extract (EECD). 100 and 200 mg/kg of EECD were treated in rats (Sprague Dawley) for 30 days and induced with MI by isoproterenol 85mg/kg on 29th and 30th day. Invasive blood pressure (IBP) and electrocardiogram (ECG) showed the improvement (p<0.001) and serum cardiac markers (aspartate aminotransferase, lactate dehydrogenase, creatinine kinase, and alanine aminotransferase) were significantly (p<0.001) reduced after the treatment with EECD. This study indicated the cardioprotection by EECD in MI conditions.
- Subjects
MYOCARDIAL infarction; ISOPROTERENOL; ALANINE aminotransferase; ASPARTATE aminotransferase; LACTATE dehydrogenase
- Publication
Malaysian Journal of Medicine & Health Sciences, 2023, Vol 19, p52
- ISSN
1675-8544
- Publication type
Case Study