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- Title
Effect of two pyrazine-containing chemosignals on cells of bone marrow and testes in male house mice ( Mus musculus L.).
- Authors
Daev, E.; Vyborova, A.; Kazarova, V.; Dukel'skaya, A.
- Abstract
The evolutionarily conservative 2,5-dimethylpyrazine chemosignal, a pheromone released by female mice, has been shown to increase frequency of mitotic disturbances in bone marrow cells assessed by using metaphase and ana-telophase analyses. The substitution of methyl radical in the molecule of pheromone by carboxyl reveals specificity of the effect of the latter derivative: the frequency of disturbances revealed by the ana-telophase analysis alone increases, whereas no induction of disturbance is detected by the metaphase analysis. An increase of the anomalies induced by both compounds has been shown in a sperm head test. Possible mechanisms underlying specific action of the tested substances on stability of the genetic apparatus of bone marrow dividing cells in the house mouse are discussed.
- Subjects
PYRAZINES; PHEROMONES; BONE marrow; MICE; MUS
- Publication
Journal of Evolutionary Biochemistry & Physiology, 2012, Vol 48, Issue 1, p18
- ISSN
0022-0930
- Publication type
Article
- DOI
10.1134/S0022093012010033