We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association of Endothelin-1 rs5370 G>T gene polymorphism with the risk of nephrotic syndrome in children.
- Authors
Hashemi, Mohammad; Sadeghi-Bojd, Simin; Aryanezhad, Soheib; Rezaei, Maryam
- Abstract
Background: Primary nephrotic syndrome (NS) is a common kidney disease in children. Objectives: The present study was aimed to investigate whether rs5370 G>T (lys198Asn) genetic variant of endothelin-1 (ET-1) is involved in the susceptibility to NS. Patients and Methods: This case-control study was performed on 138 patients with NS and 150 healthy children. Genomic DNA was extracted from whole blood using salting out method. Polymorphism of the ET-1 rs5370 G>T (lys198Asn) polymorphism detected by T-ARMS-PCR as well as PCR-RFLP method. Results: The results showed that the genotype and allelic frequencies of the ET-1 rs5370 G>T variant were not significantly different between cases and controls. Furthermore, subgroup analysis showed that rs5370 G>T variant was not associated with gender of patients. In NS patients the genotype was not associated with cholesterol, triglyceride, total protein and albumin levels. Conclusions: In conclusion, our findings indicate that ET-1 rs5370 G>T is not associated with NS. Further studies with larger sample sizes and different ethnicities are required to validate our findings.
- Subjects
NEPHROTIC syndrome diagnosis; PREPROENDOTHELIN; GENETIC polymorphisms
- Publication
Journal of Nephropathology, 2017, Vol 6, Issue 3, p138
- ISSN
2251-8363
- Publication type
Article
- DOI
10.15171/jnp.2017.24