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- Title
Comparison of serum creatinine, point-of-care symmetric dimethylarginine and renal imaging with glomerular filtration rate measured by renal scintigraphy in healthy and early chronic kidney diseased cats.
- Authors
da Cruz Schaefer, Gabriela; de Mattos Brose, Mariana; Herrera Becerra, José Ricardo; Bernhardt Rovaris, Inácio; Peixoto da Silva Mello, Fabíola; Schneck Simão, Bianca; de Faria Valle, Stella; Poletto Ferreira, Márcio; Vieira Amorim da Costa, Fernanda
- Abstract
The aim of this study was to evaluate routinely used tests to diagnose cats in early stages of chronic kidney disease (CKD) and to describe a model for evaluating these variables simultaneously. Apparently healthy cats were screened using serum creatinine (sCr), point-of-care symmetric dimethylarginine (POC SDMA), urinalysis, urine protein/creatinine ratio (UPC) and imaging evaluation. Those parameters were compared to glomerular filtration rate (GFR) assessed by renal scintigraphy. Forty-four cats were included and consisted of 14 (31.8%) healthy cats (absence of abnormalities in renal morphology and sCr less than 1.6 mg/dL), 20 (45.5%) cats classified as CKD I (presence of abnormalities in renal morphology and sCr less than 1.6 mg/dL) and ten (22.7%) as CKD II (sCr equal to or greater than 1.6 mg/dL, with or without abnormalities in renal morphology). A large number (40.9%) of apparently healthy cats presented reduction in GFR, which included half of CKD I patients. Point-of-care SDMA was not a good predictor for decreased GFR, nor was it correlated with the variables GFR and sCr. Glomerular filtration rate was significantly lower in CKD I and II groups in comparison with healthy cats, but there was no significant difference between the CKD I and II groups. Multivariate logistic regression model identified three variables that affected the odds of a cat having decreased GFR (< 2.5 mL/min/kg): sCr (OR = 18.3; p = 0.019; CI = 1.6–207.2), and the ultrasonographic findings 'reduced corticomedullary definition' (OR = 19.9; p = 0.022; CI = 1.6–254.0) and 'irregular contour' (OR = 65.6; p = 0.003; CI = 4.2–1038.2). Renal ultrasonography evaluation should always be considered for screening early CKD in apparently healthy cats.
- Publication
Veterinary Research Communications, 2023, Vol 47, Issue 4, p1845
- ISSN
0165-7380
- Publication type
Article
- DOI
10.1007/s11259-023-10131-z