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- Title
Switching to emtricitabine, tenofovir and rilpivirine as single tablet regimen in virologically suppressed HIV-1-infected patients: a cohort study.
- Authors
Gantner, P; Reinhart, S; Partisani, M; Baldeyrou, M; Batard, M‐L; Bernard‐Henry, C; Cheneau, C; Mautort, E; Priester, M; Fafi‐Kremer, S; Muret, P; Rey, D
- Abstract
Objectives Emtricitabine/tenofovir/rilpivirine as a single-tablet regimen ( STR) is widely used without licence in treatment-experienced patients. The purpose of this retrospective observational study was to assess viral suppression of ART-experienced patients switching to STR. Methods We assessed 131 pretreated patients switching to STR with HIV RNA < 400 HIV-1 RNA copies/mL. The primary outcome measure was the proportion of patients at week 24 with HIV RNA < 40 copies/mL. Results By week 24, eight patients had stopped STR: four because of adverse events and four for other reasons. Three virological failures were observed; among these, at least one patient developed cross-resistance to nucleoside reverse transcriptase inhibitors ( NRTIs) and nonnucleoside reverse transcriptase inhibitors ( NNRTIs), in particular with the E138K pattern. In intent-to-treat analysis, 92% of participants (120 of 131) achieved HIV RNA < 40 copies/mL. Only grade 1 to 2 adverse events were observed, mainly consisting of increased liver enzymes (n = 33). Systemic exposure to rilpivirine was above the usually observed steady-state levels for the 18 measurements assessed. Conclusions Efficacy and tolerability are similar to those in treatment-naïve patients.
- Subjects
FRANCE; EMTRICITABINE; TENOFOVIR; RILPIVIRINE; ACADEMIC medical centers; COMBINATION drug therapy; FISHER exact test; HIV infections; SCIENTIFIC observation; VIRAL load; TREATMENT effectiveness; RETROSPECTIVE studies; DESCRIPTIVE statistics; THERAPEUTICS
- Publication
HIV Medicine, 2015, Vol 16, Issue 2, p132
- ISSN
1464-2662
- Publication type
Article
- DOI
10.1111/hiv.12183