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- Title
Mosaic expression of uncein and 180-kDa bullous pemphigoid antigen in generalized atrophic benign epidermolysis bullosa.
- Authors
Matsumura, Y.; Horiguchi, Y.; Toda, K.; Fujii, H.; Kore-Eda, S.; Tachibana, T.; Ohta, K.; Okamoto, H.; Imamura, S.
- Abstract
Immunofluorescence microscopy of epidermodermal junction components in serial cryosections from the perilesional skin of a patient with generalized atrophic benign epidermolysis bullosa (GABEB) showed broken line-like staining of both BPAG2 (180-kDa bullous pemphigoid antigen) and uncein (antigen of 19-DEJ-1 monoclonal antibody), whereas integrin α6 and laminin 5 were continuously expressed along the basement membrane zone. Immunoelectron microscopy revealed a mosaic distribution of the BPAG2/uncein positive and negative cells. BPAG2, a candidate protein of GABEB, probably has a close connection with uncein, an anchoring filament component.
- Subjects
IMMUNOFLUORESCENCE; MICROSCOPY; EPIDERMOLYSIS bullosa; IMMUNOGLOBULINS; IMMUNOLOGY technique; GLOBULINS
- Publication
British Journal of Dermatology, 1997, Vol 136, Issue 5, p757
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1997.tb03666.x