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- Title
Spironolactone therapy for hirsute women.
- Authors
Barth, J. H.; Cherry, C. A.; Wojnarowska, F.; Dawber, R. P. R.
- Abstract
This article reports that anti-androgens are now standard treatment for hirsuties. The most widely used regimen is combination therapy with oestrogen and cyproterone acetate. However, there are many patients who either cannot tolerate this therapy or in whom it is contra-indicated. There are subjective reports that spironolactone, which is also a potent anti-androgen, is an effective therapy for hirsuties. Researchers have, therefore, made an objective study of its efficacy using a clinical scoring system and direct measures of daily growth rates and shaft diameter of facial, forearm, abdominal and thigh hair. Researchers have treated 18 premenopausal hirsute women with spironolactone for a period of 12 months. This duration was chosen to ensure that the maximum improvement could be measured and to exclude any seasonal variation in hair growth.
- Subjects
ANDROGENS; ANDROSTANE; HYPERTRICHOSIS; THERAPEUTICS; STEROID hormones; ACETATES; ESTROGEN
- Publication
British Journal of Dermatology, 1988, Vol 119, p17
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1988.tb05340.x