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- Title
The pathogenesis of amiodarone-induced pigmentation and photosensitivity.
- Authors
Zachary, C.B.; Slater, D.N.; Holt, D.W.; Storey, G.C.A.; MacDonald, D.M.
- Abstract
A new method has been used to measure tissue levels of amiodarone and its major metabolite desethylamiodarone. Amiodarone-pigmented skin has a drug and metabolite concentration ten times that of non-pigmented skin. Iodine-rich amiodarone and its metabolite have been detected in secondary lysosomes by energy dispersive analysis of X-rays. Amiodarone induces a phototoxic reaction with an action spectrum in both the UV-B and UV-A wavelengths.
- Subjects
AMIODARONE; HISTOLOGY; HUMAN skin color; MYOCARDIAL depressants; VASODILATORS; KETONES; TISSUES
- Publication
British Journal of Dermatology, 1984, Vol 110, Issue 4, p451
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1984.tb04660.x