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- Title
The Role of Stellate Cells in Pancreatic Ductal Adenocarcinoma: Targeting Perspectives.
- Authors
Wu, Yang; Zhang, Chun; Jiang, Kuirong; Werner, Jens; Bazhin, Alexandr V.; D'Haese, Jan G.
- Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal malignancy with a dismal clinical outcome. Accumulating evidence suggests that activated pancreatic stellate cells (PSCs), the major producers of extracellular matrix (ECM), drive the severe stromal/desmoplastic reaction in PDAC. Furthermore, the crosstalk among PSCs, pancreatic cancer cells (PCCs) as well as other stroma cells can establish a growth-supportive tumor microenvironment (TME) of PDAC, thereby enhancing tumor growth, metastasis, and chemoresistance via various pathways. Recently, targeting stroma has emerged as a promising strategy for PDAC therapy, and several novel strategies have been proposed. The aim of our study is to give a profound review of the role of PSCs in PDAC progression and recent advances in stroma-targeting strategies.
- Subjects
GASTROINTESTINAL cancer; ADENOCARCINOMA; TUMOR microenvironment; CANCER cells; TUMOR growth
- Publication
Frontiers in Oncology, 2021, Vol 11, pN.PAG
- ISSN
2234-943X
- Publication type
Article
- DOI
10.3389/fonc.2020.621937