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- Title
Enzyme Inhibition Studies on N-Substituted Sulfonamides Derived from m-phenetidine.
- Authors
Aziz-ur-Rehman; Siddiqa, A.; Abbasi, M. A.; Rasool, S.; Siddiqui, S. Z.; Gul, S.; Ashraf, M.; Nasar, R.
- Abstract
Organic synthesis of various compounds followed by biological activities is the going on methodology in the world for pharmacological evaluation. The undertaken research is the synthesis of N-(3-ethoxyphenyl)-4-methylbenzenesulfonamide (3) through condensation reaction of m-phenetidine (1) and 4-methylbenzenesulfonyl chloride (2) using basic aqueous media of sodium carbonate. Further, the synthesized compound 3 was reacted with different alkyl/aralkyl halides (4a-j) using DMF as aprotic polar solvent and NaH as a base to yield 5a-j compounds. The synthesized molecules were characterized from their spectral data. The synthesized compounds were evaluated against cholinesterase (AChE and BChE), lipoxygenase (LOX), urease, chymotrypsin and tyrosinase enzymes; and found to be the moderate inhibitor against tyrosinase enzyme.
- Subjects
ENZYME inhibitors; SULFONAMIDES; PHENYL ethers; SUBSTITUTION reactions; ORGANIC synthesis; CHLORIDES; CONDENSATION reactions
- Publication
Pakistan Journal of Chemistry, 2013, Vol 3, Issue 3, p100
- ISSN
2220-2625
- Publication type
Article
- DOI
10.15228/2013.v03.i03.p02