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- Title
Enzymatic Synthesis of Novel Bavachinin Glucoside by UDP-glycosyltransferase.
- Authors
Dai, Yiqun; Ma, Tao; Ge, Min; Li, Jing; Huo, Qiang; Li, Hong‐Mei; Zhang, Xinyu; Liu, Hao; Wu, Cheng‐Zhu
- Abstract
Bavachinin, a member of the flavanone subclass of flavonoids, has long been considered to have various biological activities. Here, the synthesis of novel bavachinin glucoside by the in vitro glycosylation reaction was successfully achieved using a UDP-glucosyltransferase YjiC, from Bacillus licheniformis DSM-13. The chemical structure of bavachinin glucoside was characterized based on spectroscopic techniques as bavachinin-4′- O-ß-D-glucopyranoside ( 1). The water-solubility of bavachinin-4′- O-ß-D-glucopyranoside was found to be 9.96 μM, about 10 times higher than bavachinin. In addition, compound 1 showed moderate anti-proliferative activity against four human tumor cell lines, with IC50 values ranging from 48.5 to 61.4 μM.
- Subjects
GLUCOSIDES; GLYCOSYLATION; GLYCOSYLTRANSFERASES; BACILLUS licheniformis; FLAVONOIDS
- Publication
Journal of the Chinese Chemical Society, 2016, Vol 63, Issue 4, p376
- ISSN
0009-4536
- Publication type
Article
- DOI
10.1002/jccs.201500497