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- Title
Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas.
- Authors
Nagai, H.; Naka, T.; Terada, Y.; Komazaki, T.; Yabe, A.; Jin, E.; Kawanami, O.; Kishimoto, T.; Konishi, N.; Nakamura, M.; Kobayashi, Y.; Emi, M.
- Abstract
We recently demonstrated inactivation in hepatocellular carcinomas (HCCs) of the gene encoding SOCS1/ JAB1/SSI-1, a JAK-binding protein that regulates the JAK/STAT signal-transduction pathway. In a follow-up immunochemical investigation of expression of SOCS-1 in hepatoblastomas (HBLs), the protein was markedly reduced in half of the HBL tumors we examined. CpGrich regions upstream of the SOCS-1 gene were hypermehylated in 7 of the 15 HBL cases. The results suggest that hypermethylation may play an important role in silencing the SOCS-1 gene, not only in adult HCCs, but also in liver tumors arising in childhood.
- Subjects
LIVER cancer; METHYLATION; MOLECULAR genetics
- Publication
Journal of Human Genetics, 2003, Vol 48, Issue 2, p65
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s100380300008