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- Title
Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity.
- Authors
Guo, Hongbo; de Vries, Erik; McBride, Ryan; Dekkers, Jojanneke; Wenjie Peng; Bouwman, Kim M.; Nycholat, Corwin; Verheije, M. Helene; Paulson, James C.; van Kuppeveld, Frank J. M.; de Haan, Cornelis A. M.; Peng, Wenjie
- Abstract
Emergence and intercontinental spread of highly pathogenic avian influenza A(H5Nx) virus clade 2.3.4.4 is unprecedented. H5N8 and H5N2 viruses have caused major economic losses in the poultry industry in Europe and North America, and lethal human infections with H5N6 virus have occurred in Asia. Knowledge of the evolution of receptor-binding specificity of these viruses, which might affect host range, is urgently needed. We report that emergence of these viruses is accompanied by a change in receptor-binding specificity. In contrast to ancestral clade 2.3.4 H5 proteins, novel clade 2.3.4.4 H5 proteins bind to fucosylated sialosides because of substitutions K222Q and S227R, which are unique for highly pathogenic influenza virus H5 proteins. North American clade 2.3.4.4 virus isolates have retained only the K222Q substitution but still bind fucosylated sialosides. Altered receptor-binding specificity of virus clade 2.3.4.4 H5 proteins might have contributed to emergence and spread of H5Nx viruses.
- Subjects
INFLUENZA A virus; POULTRY diseases; INFLUENZA transmission; POULTRY industry; HEMAGGLUTININ; AVIAN influenza epidemiology; INFLUENZA epidemiology; ALLELES; AMINO acids; ANIMAL experimentation; AVIAN influenza; BIOCHEMISTRY; CELL receptors; COMPARATIVE studies; BIOLOGICAL evolution; INFLUENZA; PHENOMENOLOGY; RESEARCH methodology; MEDICAL cooperation; GENETIC mutation; POULTRY; PROTEINS; RESEARCH; VIRUSES; VIRAL physiology; EVALUATION research; GENOTYPES; PHYSIOLOGY
- Publication
Emerging Infectious Diseases, 2017, Vol 23, Issue 2, p220
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2302.161072