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- Title
Geographic distribution and genetic diversity of Whitewater Arroyo virus in the southwestern United States.
- Authors
Fulhorst, Charles F.; Weaver, Scott C.; Milazzo, Mary L.; Tesh, Robert B.; Charrel, Remi N.; Ksiazek, Thomas G.; Bowen, Michael D.; Bradley, Robert D.; Fulhorst, C F; Charrel, R N; Weaver, S C; Ksiazek, T G; Bradley, R D; Milazzo, M L; Tesh, R B; Bowen, M D
- Abstract
The purpose of this study was to extend our knowledge of the geographic distribution and genetic diversity of the arenavirus(es) associated with Neotoma species (woodrats) in the southwestern United States. Infectious arenavirus was recovered from 14 (3.3%) of 425 woodrats. The virus-positive species included N. albigula in New Mexico and Oklahoma, N. cinerea in Utah, N. mexicana in New Mexico and Utah, and N. micropus in Texas. Analyses of viral nucleocapsid protein gene sequence data indicated that all the isolates were strains of the Whitewater Arroyo virus, an arenavirus previously known only from northwestern New Mexico. Analyses of the sequence data also indicated that there can be substantial genetic diversity among strains of Whitewater Arroyo virus from conspecific woodrats collected from different localities and substantial genetic diversity among strains from different woodrat species collected from the same locality.
- Subjects
SOUTHWESTERN United States; UNITED States; ARENAVIRUS diseases; WOOD rats; VIRUSES; INFECTIOUS disease transmission; ANIMAL experimentation; COMPARATIVE studies; BIOLOGICAL evolution; GENETICS; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RNA viruses; RODENTS; EVALUATION research
- Publication
Emerging Infectious Diseases, 2001, Vol 7, Issue 3, p403
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid0703.010306