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- Title
Litsea Species as Potential Antiviral Plant Sources.
- Authors
Guan, Yifu; Wang, Dongying; Tan, Ghee T.; Van Hung, Nguyen; Cuong, Nguyen Manh; Pezzuto, John M.; Fong, Harry H.S.; Soejarto, Djaja Doel; Zhang, Hongjie
- Abstract
Litsea verticillata Hance (Lauraceae), a Chinese medicine used to treat swelling caused by injury or by snake bites, was the first plant identified by our National Institutes of Health (NIH)-funded International Cooperative Biodiversity Group (ICBG) project to exhibit anti-HIV activities. From this plant, we discovered a class of 8 novel litseane compounds, prototypic sesquiterpenes, all of which demonstrated anti-HIV activities. In subsequent studies, 26 additional compounds of different structural types were identified. During our continuing investigation of this plant species, we identified two new litseanes, litseaverticillols L and M, and a new sesquiterpene butenolide, litseasesquibutenolide. Litseaverticillols L and M were found to inhibit HIV-1 replication, with an IC value of 49.6M. To further determine the antiviral properties of this plant, several relatively abundant isolates, including a litseane compound, two eudesmane sesquiterpenes and three lignans, were evaluated against an additional 21 viral targets. Lignans 8 and 9 were shown to be active against the Epstein-Barr Virus (EBV), with EC values of 22.0M () and 16.2M (), respectively. Since many antiviral compounds have been discovered in L. verticillata, we further prepared 38 plant extracts made from the different plant parts of 9 additional Litsea species. These extracts were evaluated for their anti-HIV and cytotoxic activities, and four of the extracts, which ranged across three different species, displayed 97-100% inhibitory effects against HIV replication without showing cytotoxicity to a panel of human cell lines at a concentration of 20g/mL.
- Subjects
ANTIVIRAL agent analysis; ANIMAL experimentation; ANTIVIRAL agents; BIOLOGICAL assay; CELL culture; CHROMATOGRAPHIC analysis; EPSTEIN-Barr virus; HIV; HIV infections; MASS spectrometry; MOLECULAR structure; NUCLEAR magnetic resonance spectroscopy; PHARMACEUTICAL chemistry; RESEARCH funding; TERPENES; TOXICITY testing; VIRUSES; PLANT extracts
- Publication
American Journal of Chinese Medicine, 2016, Vol 44, Issue 2, p275
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X16500166