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- Title
MRP8/14 and neutrophil elastase for predicting treatment response and occurrence of flare in patients with juvenile idiopathic arthritis.
- Authors
Barendregt, Anouk M; Veldkamp, Saskia R; Muller, Petra C E Hissink; van de Geer, Annemarie; Aarts, Cathelijn; Gulik, E Charlotte van; Schilham, Marco W; Kessel, Christoph; Keizer, Mischa P; Hemke, Robert; Rashid, Amara Nassar-Sheikh; Dolman, Koert M; Schonenberg-Meinema, Dieneke; Cate, Rebecca ten; Berg, J Merlijn van den; Maas, Mario; Kuijpers, Taco W
- Abstract
Objective To study two neutrophil activation markers, myeloid-related protein (MRP) 8/14 and neutrophil elastase (NE), for their ability to predict treatment response and flare in patients with JIA. Methods Using samples from two cohorts (I and II), we determined MRP8/14 and NE levels of 32 (I) and 81 (II) patients with new-onset, DMARD-naïve arthritis and compared patients who responded to treatment (defined as fulfilling ≥ adjusted ACRpedi50 response and/or inactive disease) with non-responders (defined as fulfilling < adjusted ACRpedi50 response and/or active disease) at 6 and 12 months. Secondly, we compared biomarker levels of 54 (I) and 34 (II) patients with clinically inactive disease who did or did not suffer from a flare of arthritis after 6 or 12 months. Receiver operating characteristic analyses were carried out to study the predictive value of MRP8/14 and NE for treatment response and flare. Results For both cohorts, baseline MRP8/14 and NE levels for patients who did or did not respond to treatment were not different. Also, MRP8/14 and NE levels were not different in patients who did or did not flare. Receiver operating characteristic analysis of MRP8/14 and NE demonstrated areas under the curve <0.7 in both cohorts. Conclusion In our cohorts, MRP8/14 and NE could not predict treatment response. Also, when patients had inactive disease, neither marker could predict flares.
- Subjects
BIOMARKERS; CALCIUM-binding proteins; LONGITUDINAL method; PROTEOLYTIC enzymes; JUVENILE idiopathic arthritis; DISEASE relapse; TREATMENT effectiveness; RECEIVER operating characteristic curves; DESCRIPTIVE statistics
- Publication
Rheumatology, 2020, Vol 59, Issue 9, p2392
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/kez590