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- Title
Leukaemic stem cells.
- Authors
Blair, A.; Pamphilon, D. H.
- Abstract
All haemopoietic cell lineages arise from multipotential self-renewing stem cells that give rise to committed progenitor cells. These progenitor cells subsequently differentiate into more lineage-committed cells with a restricted range of plasticity. A hierarchical order is considered to exist, where lineage commitment and differentiation are thought to be irreversible. As cells differentiate, they gradually lose the ability to self-renew. The most primitive haemopoietic progenitor cells have the ability to reconstitute long-term haemopoiesis in myeloablated recipients. However, as cells differentiate, there is an orchestrated silencing of some genes and activation of others, resulting in lineage commitment and generally a reduction in proliferative ability. Here, we discuss potential differences between normal and leukaemic stem cells, some of which may have therapeutic implications.
- Subjects
STEM cells; HEMATOPOIESIS; LEUKEMIA immunology; GENES
- Publication
Transfusion Medicine, 2003, Vol 13, Issue 6, p363
- ISSN
0958-7578
- Publication type
Article
- DOI
10.1111/j.1365-3148.2003.00464.x