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- Title
Whole genome linkage scan of recurrent depressive disorder from the depression network study.
- Authors
McGuffin, Peter; Knight, Jo; Breen, Gerome; Brewster, Shyama; Boyd, Peter R.; Craddock, Nick; Gill, Mike; Korszun, Ania; Maier, Wolfgang; Middleton, Lefkos; Mors, Ole; Owen, Michael J.; Perry, Julia; Preisig, Martin; Reich, Theodore; Rice, John; Rietschel, Marcella; Jones, Lisa; Sham, Pak; Farmer, Anne E.
- Abstract
Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for female–female pairs exceeded 3 (but reduced to 2.73 when corrected for multiple testing). The region includes a gene, MTHFR, that in previous studies has been associated with depressive symptoms. Two other regions, on chromosomes 12q23.3–q24.11 and 13q31.1–q31.3, showed evidence for linkage with a nominal P<0.01. The 12q peak overlaps with a region previously implicated by linkage studies of unipolar and bipolar disorders and contains a gene, DAO, that has been associated with both bipolar disorder and schizophrenia. The 13q peak lies within a region previously linked strongly to panic disorder. A fourth modest peak with an LOD of greater than 1 on chromosome 15q lies within a region that showed genome-wide significant evidence of a recurrent depression locus in a previous sib-pair study. Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined.
- Publication
Human Molecular Genetics, 2005, Vol 14, Issue 22, p3337
- ISSN
0964-6906
- Publication type
Article
- DOI
10.1093/hmg/ddi363