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- Title
Ets transcription factor GABP controls T cell homeostasis and immunity.
- Authors
Luo, Chong T.; Osmanbeyoglu, Hatice U.; Do, Mytrang H.; Bivona, Michael R.; Toure, Ahmed; Kang, Davina; Yuchen Xie; Leslie, Christina S.; Li, Ming O.
- Abstract
Peripheral T cells are maintained in the absence of vigorous stimuli, and respond to antigenic stimulation by initiating cell cycle progression and functional differentiation. Here we show that depletion of the Ets family transcription factor GA-binding protein (GABP) in T cells impairs T-cell homeostasis. In addition, GABP is critically required for antigen-stimulated T-cell responses in vitro and in vivo. Transcriptome and genome-wide GABP-binding site analyses identify GABP direct targets encoding proteins involved in cellular redox balance and DNA replication, including the Mcm replicative helicases. These findings show that GABP has a nonredundant role in the control of T-cell homeostasis and immunity.
- Subjects
TRANSCRIPTION factors; HOMEOSTASIS; DNA replication; CELL cycle; IMMUNITY; T cells
- Publication
Nature Communications, 2017, Vol 8, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-017-01020-6