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- Title
FORMULATION, CHARACTERIZATION AND OPTIMIZATION OF GASTRORETENTIVE HYDROGEL TABLET CONTAINING CEFIXIME TRIHYDRATE.
- Authors
Devi, Lalita; Gaba, Punam
- Abstract
In present study focused has been made to formulate gastroretentive drug delivery system (GRDDS) of drug having narrow absorption window or having good absorption at proximal part of gastrointestinal tract (GIT) to deliver at stomach site and to improve the bioavailbility of drug. Gastroretentive hydrogel tablet of Cefixime trihydrate were prepared by direct compression technique by using carbopol 940 and chitosan with different concentration. Cefixime is a very poorly water soluble drug after its oral administration; so that it is slowly and incompletely absorbed from the gastrointestinal tract, which resulting into the poor bioavailability i.e., 40-50%. Hydrogel were characterized with respect to various parameters such as swelling ratio, mechanical strength, in vitro drug release etc. The drug release from Combination of carbopol 940 and chitosan based hydrogel showed for prolonged period of time. A 3² full factorial design was used to optimize the tablet of cefixime trihydrate by selecting amount of carbopol 940 and chitosan as independent variables and effects were observerd on drug release and swelling index. The antimicrobial activity against S. aureus and E. coli was determined. The optimized batch gave desired results at 16hr as time for 85% drug release and % swelling index as 93% achieved. Stability studies showed no change in physical appearance and insignificant difference in drug release and swelling index.
- Subjects
HYDROGELS; ORAL medication; GASTROINTESTINAL system; DRUG delivery systems; FACTORIAL experiment designs
- Publication
International Journal of Pharmacy & Life Sciences, 2019, Vol 10, Issue 6, p53
- ISSN
0976-7126
- Publication type
Article