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- Title
Chimaeras Obtained by Aggregation of Mouse Eggs with Rat Eggs.
- Authors
STERN, M. SUSAN
- Abstract
TECHNIQUES have been developed which enable mouse eggs differing in age and stage of development to aggregate and form large but apparently morphologically normal blastocysts capable of egg cylinder formation at least1,2. Such chronological regulation has also been demonstrated for the mouse blastocyst by transfer of an isolated 4.5-day inner cell mass to a 3.5-day blastocyst with the subsequent formation of a normal chimaera3. These systems show that chimaeras derived from two components with the same pattern of differentiation, but with a temporal discrepancy experimentally imposed, can develop normally. This suggests that rat and mouse eggs, in which the pattern of differentiation is similar but on a different time scale, might develop successfully when aggregated together. This hypothesis was supported by a pilot study4 which has been extended and is reported here.
- Publication
Nature, 1973, Vol 243, Issue 5408, p472
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/243472a0