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- Title
Pancreatic Steatosis and Its Relationship to β-Cell Dysfunction in Humans.
- Authors
SZCZEPANIAK, LIDIA S.; VICTOR, RONALD G.; MATHUR, RUCHI; NELSON, MICHAEL D.; SZCZEPANIAK, EDWARD W.; TYER, NICOLE; CHEN, IDA; UNGER, ROGER H.; BERGMAN, RICHARD N.; LINGVAY, ILDIKO
- Abstract
OBJECTIVE--To evaluate racial/ethnic differences in pancreatic triglyceride (TG) levels and their relationship to β-cell dysfunction in humans. RESEARCH DESIGN AND METHODS--We studied black, Hispanic, and white adults who completed three research visits: screening and an oral glucose tolerance test; frequently sampled intravenous glucose tolerance tests for evaluation of β-cell function and insulin resistance; and proton magnetic resonance spectroscopy for evaluation of pancreatic and hepatic TG levels. RESULTS--Pancreatic TG levels were higher in Hispanics and whites than in blacks (P = 0.006). Hepatic TG levels were highest in Hispanics (P = 0.004). Compensatory insulin secretion and disposition index were higher in blacks (P = 0.003 and P = 0.024, respectively). Insulin sensitivity was comparable between Hispanics and blacks and was lower than in whites (P = 0.005). In blacks, compensatory insulin secretion increased steeply with small increments in pancreatic TG levels (R⊃2 = 0.45, slope = 247). In whites, the range of pancreatic TG levels was higher, and the slope was less steep than in blacks (R⊃2 = 0.27, slope = 27). In Hispanics, pancreatic TG levels were similar to those of whites, but compensatory insulin secretion was described by a combination of pancreatic and hepatic TG levels and visceral fat mass ( R⊃2 = 0.32). CONCLUSIONS--In a multiethnic sample of adults with mild obesity and without diabetes, we found striking ethnic differences in the levels of pancreatic TGs and in the relationship between pancreatic TGs and β-cell dysfunction. Our data implicate pancreatic TG content measured by proton magnetic resonance spectroscopy as a noninvasive novel biomarker for pancreatic β-cell dysfunction, especially in the Hispanic population.
- Subjects
TRIGLYCERIDES; INSULIN resistance; HISPANIC Americans; PANCREAS; INSULIN research
- Publication
Diabetes Care, 2012, Vol 35, Issue 11, p2377
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc12-0701