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- Title
Tissue optical clearing enhances efficacy of vascular targeted photodynamic therapy of mouse dorsal skin.
- Authors
Liu, Ying; Wang, Qiushi; Liu, Yidi; Wang, Ying; Qiu, Haixia; Zhu, Dan; Gu, Ying; Chen, Defu
- Abstract
Vascular-targeted photodynamic therapy (V-PDT) is an effective treatment for port wine stains (PWS). However, repeated treatment is usually needed to achieve optimal treatment outcomes, possibly due to the limited treatment light penetration depth in the PWS lesion. The optical clearing technique can increase light penetration in depth by reducing light scattering. This study aimed to investigate the V-PDT in combination with an optical clearing agent (OCA) for the therapeutic enhancement of V-PDT in the rodent skinfold window chamber model. Vascular responses were closely monitored with laser speckle contrast imaging (LSCI), optical coherence tomography angiography, and stereo microscope before, during, and after the treatment. We further quantitatively demonstrated the effects of V-PDT in combination with OCA on the blood flow and blood vessel size of skin microvasculature. The combination of OCA and V-PDT resulted in significant vascular damage, including vasoconstriction and the reduction of blood flow. Our results indicate the promising potential of OCA for enhancing V-PDT for treating vascular-related diseases, including PWS.
- Subjects
PHOTODYNAMIC therapy; SPECKLE interference; OPTICAL coherence tomography; BLOOD flow; SPECKLE interferometry
- Publication
Journal of Innovative Optical Health Sciences, 2024, Vol 17, Issue 2, p1
- ISSN
1793-5458
- Publication type
Article
- DOI
10.1142/S1793545823500232